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C2 Präparative Gradientenchromatographie von Proteinen

(Seidel-Morgenstern)

Publikationen/ Publications

2010

Ilić, M., Flockerzi, D. and Seidel-Morgenstern, A.. A thermodinamically consistent explicit competitive adsorption isotherm model based on second-order single component behaviour. Journal of Chromatography A, 1217, 2132 - 2137 (2010)

Li, S., Kawajiri, Y., Raisch, J. and Seidel-Morgenstern, A.. Optimization of simulated moving bed chromatography with fractionation and feedback: Part I. Fractionation of one outlet. Journal of Chromatography A, 1217, 5337 - 5348 (2010)

Li, S., Kawajiri, Y., Raisch, J. and Seidel-Morgenstern, A.. Optimization of simulated moving bed chromatography with fractionation and feedback: Part II. Fractionation of both outlets. Journal of Chromatography A, 1217, 5349 - 5357 (2010)

Ballerstein, M., Michaels, D., Seidel-Morgenstern, A. and Weismantel, R.. A theoretical study of continuous counter-current chromatography for adsorption isotherms with inflection points. Computers & Chemical Engineering, 34, 447 - 459 (2010)

2009

Keßler, L.C: Enhancing the Potential of Simulated Moving Bed Chromatography: Theoretical Studies and Experimental Validation, Ph.D. thesis, Otto-von-Guericke-Universität (2009)

Damtew A., Sreedhar B., Seidel-Morgenstern A. (2009). Evaluation of the potential of nonlinear gradients for separating a ternary mixture. Journal of Chromatography A, 1216, 5355-5364

Sreedhar B., Damtew A., Seidel-Morgenstern A. (2009). Theoretical study of preparative chromatography using closed-loop recycling with an inital gradient. Journal of Chromatography A, 1216, 4976-4988

Ilic M., Petkovska M., Seidel-Morgenstern A. (2009). Determination of competitive adsorption isotherms applying the nonlinear frequency response method. Part I. Theoretical analysis. Journal of Chromatography A, 1216, 6098-6107

Ilic M., Petkovska M., Seidel-Morgenstern A. (2009). Determination of competitive adsorption isotherms applying the nonlinear frequency response method. Part II. Experimental demonstration. Journal of Chromatography A, 1216, 6108-6118

Melnikov S.M., Höltzel A., Seidel-Morgenstern A., Tallarek U. (2009). Influence of Residual Silanol Groups on Solvent and Ion Distribution at a Chemically Modified Silica Surface. Journal of Physical Chemistry C, 113, 9230-9238

Khirevich S., Höltzel A., Seidel-Morgenstern A., Tallarek U. (2009). Time and Length Scales of Eddy Dispersion in Chromatographic Beds. Anal. Chem., 81, 7057-7066

 

2008

Kessler L. C. Enhancing the Potential of Simulated Moving BedChromatography: Theoretical Studies and Experimental Validation. Dissertation zur Erlangung des akademischen Grades Doktoringenieur. 11.2008

Ilic' M. A Nonlinear Frequency Response Method for Estimation of Single Solute and Competitive Adsorption Isotherms. Dissertation zur Erlangung des akademischen Grades Doktoringenieur. 04.2008

Sreedhar B., Seidel-Morgenstern A. (2008). Preparative separation of multi-component mixtures using stationary phase gradients. Journal of Chromatography A, 1215, 133-144

Keßler L. C., Seidel-Morgenstern A. (2008). Improving performance of Simulated Moving Bed Chromatography by Fractionation and Feed-back of outlet streams. Journal of Chromatography A, 1207, 55-71

Kalbfuss B., Flockerzi D., Seidel-Morgenstern A., Reichl U. (2008). Size-exclusion chromatography as a linear transfer system: Purification of human influenza virus as an example. Journal of Chromatography B, 873, 102-112

Ilic' M., Menka P., Seidel-Morgenstern A. (2008). Estimation of single solute adsorption isotherms applying the nonlinear frequency response method using non-optimal frequencies. Journal of Chromatography A, 1200, 183-192

Seidel-Morgenstern A., Keßler L. C., Kaspereit M. (2008). Neue Entwicklungen auf dem Gebiet der simulierten Gegenstromchromatographie. Chemie Ingenieur Technik, 80, 725-740

Seidel-Morgenstern A., Keßler L. C., Kaspereit M. (2008). New developments in simulated moving bed chromatography. Chemical Engineering and Technology, 31, 826-837

2007

Ilić M., Petkovska M., Seidel-Morgenstern A. (2007). Nonlinear frequency response functions of a chromatographic column – A critical evaluation of their potential for estimation of single solute adsorption isotherms. Chemical Engineering Science, 62, 1269-1281

Lübke R., Seidel-Morgenstern A., Tobiska L. (2007). Numerical method for accelerated calculation of cyclic steady state of ModiCon-SMB-processes. Computer & Chemical Engineering, 31, 258-267

Ilić M., Petkovska M., Seidel-Morgenstern A. (2007). Nonlinear frequency response method for estimation of single solute adsorption isotherms. Part I. Theoretical basis and simulations. Chemical Engineering Science, 62, 4379-4393

Ilić M., Petkovska M., Seidel-Morgenstern A. (2007). Nonlinear frequency response method for estimation of single solute adsorption isotherms. Part II. Experimental study. Chemical Engineering Science, 62, 4394-4408

Kaspereit M., Seidel-Morgenstern A., Kienle A. (2007). Design of simulated moving bed processes under reduced purity requirements. Journal of Chromatography A, 1162, 2-13

Gedicke K., Antos D., Seidel-Morgenstern A. (2007). Effect on separation of injecting samples in a solvent different from the mobile phase. Journal of Chromatography A, 1162, 62-73

Haus U.-U., Michaels D., Seidel-Morgenstern A., Weismantel R. (2007). A method to evaluate the feasibility of TMB chromatography for reduced efficiency and purity requirements based on discrete optimization. Computers & Chemical Engineering, 31, 1525-1534

Kessler L. C., Gueorguieva L., Rinas U., Seidel­-Morgenstern A. (2007). Step gradients in 3-zone simulated moving bed chromatography – Application to the purification of antibodies and bone morphogenetic protein-2. Journal of Chromatography A, 1176, 69-78

Ilic M., Petkovska M., Seidel­-Morgenstern A. (2007). Theoretical investigation of the adsorption of a binary mixture in a chromatographic column using the nonlinear frequency response technique. Adsorption, 13, 541-567

Lübke, R., Seidel-Morgenstein, A., Tobiska, L. (2007). Numerical method for accelerated calculation of cyclic steady state of ModiCon-SMB-processes. Computers and Chemical Engineering 31, 258 – 267

Ilic, M., Petkovska, M., Seidel-Morgenstern, A. (2007). Nonlinear frequency response functions of chromatographic column-A critical evaluation of their potential for estimation of single solute adsorption isotherms. Chemical Engineering Science 62, 1269-1281

2006

Joshi, M., Kremling, A., Seidel-Morgenstern, A. (2006). Model based statistical analysis of adsorption equilibrium data. Chemical Engineering Science 61, 7805-7818

Gueorguieva, L., Vallejo, L.F., Rinas, U. and Seidel-Morgenstern, A. (2006). Discontinuous and continuous separation of the monomeric and dimeric forms of human bone morphogenetic protein-2 from renaturation batches. J. Chromatogr. A, 1135, 142-150

Keßler, L. C., Seidel-Morgenstern, A. (2006). Theoretical study of multicomponent continuous countercurrent chromatography based on connected 4-zone units. Journal of Chromatography A, 1126 (1-2) 323-337

Gueorguieva, L., Vallejo, L.F., Rinas, U. and Seidel-Morgenstern, A. (2006). Discontinuous and continuous separation of the monomeric and dimeric forms of human bone morphogenetic protein-2 from renaturation batches. J. Chromatogr. A, 1135, 142-150

L. C. Kessler, A. Seidel-Morgenstern (2006). Theoretical study for multicomponent continuous countercurrent chromatography based on connected 4-zone units. Journal of Chromatography A, 1126, (1-2), 323-337

L. C. Kessler, A. Seidel-Morgenstern (2006). Neue Entwicklungen in der kontinuierlichen Gegenstromchromatographie. GIT Labor-Fachzeitschrift, 10, Vol. 50, 919-923

L. C. Kessler, A. Seidel-Morgenstern (2006). Simulated Moving Bed Chromatography : Separation of a Ternary Mixture. GIT Laboratory Journal, 3, Vol. 10, 43 - 45

L. C. Kessler, A. Seidel-Morgenstern (2006). Simulierte Gegenstromchromatographie. GIT Labor-Fachzeitschrift, 5, Vol. 50, 473 - 476

G. Ziomek, D. Antos, L. Tobisk, A. Seidel-Morgenstern (2006). Comparison of possible arrangements of five identical columns in preparative chromatography. Journal of Chromatography A, 1-2, Voll. 116, 179 - 188

W. Zhang, Y. Shan, A. Seidel-Morgenstern (2006). Breakthrough curves and elution profiles of single solutes in case of adsorption isotherms with two inflection points. Journal of Chromatography A, 1-2, Vol. 1107, 216 - 225

Y. Shan, W. Zhang, A. Seidel-Morgenstern, R. Zhao, Y. Zhang (2006). Multi-segment linear gradient optimization strategy based on resolution map in HPLC. Science in China Press, 2, Vol. 26, 130 - 138

W. Zhang, Y. Shan, A. Seidel-Morgenstern, Y. Zhang (2006). Characteristics of elution profiles in radial chromatography under linear conditions. Science in China Ser. B, Chemistry, Vol. 48, 352- 360

2005

Seidel-Morgenstern, A. (2005). Preparativ Gradient Chromatography. Chem. Eng. Technol., 28. No. 11 (Wiley-VCH)

Shan, Y., Seidel-Morgenstern, A. (2005). Optimization of gradient elution conditions in multicomponent preparative liquid chromatography. Journal of Chromatography A, 1093, (Elsevier)

Petrovska, M., Seidel-Morgenstern, A. (2005). Nonlinear Frequency Response of a Chromatographic Column. Part I: Application to Estmation of Adsorption Isotherms with Inflection Points. Chem. Eng. Comm., 192, (Taylor & Francis)

Gedicke, K., Tomusiak, M., Antos, D., Seidel-Morgenstern, A. (2005). Analysis of applying different solvents for the mobile phase and for sample injection. Journal of Chromatography A, 1092, (Elsevier)

Kaspereit, M, Gedicke, K, Zahn, V., Mahoney A. W., Seidel-Morgenstern, A. (2005). Shortcut method for evaluation and design of a hybrid process for enatioseparations. Journal of Chromatography A, 1092, (Elsevier)

Shan, Y., Seidel-Morgenstern A. . Isolation of a Target Component from a Multi-component Mixture by Coupling Batch and Continuous Countercurrent Chromatography. Chem Eng Technol 28, 695-708

Ziomek, G., Kaspereit, M., Jezowski, J., Seidel-Morgenstern, A., Antos, D. (2005). Effect of mobile phase composition on the SMB processes efficiency Stochastic. optimization of isocratic and gradient operation. J. Chromatography A., 1070,111-124

Gedicke, K., Beckmann, W., Bandt, A., Sapoundjiev, D., Lorenz, H., Budde, U.,. Seidel-Morgenstern, A. (2005). Coupling chromatography and crystallization for efficient enantioseparation Adoption, 11, 591-596

Weibing, Z., Yichu, S., Seidel-Morgenstern, A., Yukui, Z. (2005). Characteristics of elution profile in radial chromatography. Science in China, Ser. B. Chemistry, 35, 1 - 7

2004

Mihlbachler, K., Seidel-Morgenstern, A., Guiochon G. (2004). Separating the enantiomers of Tröger’s base using SMB chromatography. AIChE Journal, Vol. 50, 3, 611-624

Seidel-Morgenstern, A. (2004). Experimental determination of simple solute and competitive adsorption isotherms. J. Chroma. A., 1037, 255-272

Shan, Y., Seidel-Morgenstern, A. (2004). Analysis of the isolation of a target component using multicomponent isocratic preparative elution chromatography. J. Chroma. A., 1041, 53-62

2003

Schramm, H., Kaspereit, M., Kienle, A., Seidel-Morgenstern, A. (2003). Verbesesserter Betrieb von Simulated Moving Bed-Prozessen durch zyklische Modulation der Feedkonzentration. Chem.-Ing.-Techn., 75, 379-383

Antos, D., Kaczmarski, K., Piatkowski, W., Seidel-Morgenstern, A. (2003). Concentration dependence of lumped mass transfer coefficients - linear vs. nonlinear chromatography and isocratic vs. gradient operation. J. Chromat. A., 1006, 61-76

Schramm, H., Kaspereit, M., Kienle, A., Seidel-Morgenstern, A. (2003). Simulated moving bed process with cyclic modulation of the feed concentration. J. Chromat. A., 1006, 2003, 77-86

Schramm, H., Kienle, A., Kaspereit, M., Seidel-Morgenstern, A. (2003). Improved operation of simulated moving bed processes through cyclic modulation of feed flow and feed concentration. Chem. Eng. Sci., 58, 5217-227

Beltcheva, D., Hugo, P., Seidel-Morgenstern, A. (2003). Linear two-step gradient counter-current chromatography – analysis based on a recursive solution of an equilibrium stage model. J. Chromat. A. 989, 31-45

Seidel-Morgenstern A. (2003). Preparative gradient chromatography. Invited Review in the Special Issue: „100 Years Chromatography“, Russian Chemical Journal 47, 80-89

2002

Schramm, H., Kaspereit, M., Kienle, A., Seidel-Morgenstern, A. (2002). Improving simulated moving bed processes by cyclic modulation of the feed concentration. Chemical Engineering Technology 25, 1151-1155

Tallarek, U., Leinweber, F., Seidel-Morgenstern, A. (2002) . Fluid dynamics in monolithic adsorbents: Phenomenological approach to equivalent particle dimensions. Chem. Eng. Techn. 25, 1177-1181

Antos, D., Seidel-Morgenstern, A. (2002) Two-step solvent gradients in simulated moving bed chromatography - numerical study for linear equilibria. J. Chromat. A. 944/1, 77-91

Antos, D., Seidel-Morgenstern, A. (2002). Continous step gradient elution for preparative separations. Separation Science and Technology 37, 1469-1487

Antos, D., Seidel-Morgenstern, A. (2002). Application of gradients in the simulated moving bed process. Chem. Eng. Sci. 56, 6667-6682

 

Vorträge und Poster/ Conference Presentations

2007

Keßler, L.C., Gueorguieva, L., Seidel-Morgenstern, A. (2007). Step Gradients for the Purification of Proteins and Antibodies in SMB Chromatography. Talk at 20th PREP Symposium 2007, Baltimore, USA, June 3-6, 2007

Keßler, L.C., Seidel-Morgenstern, A. (2007). Improved Performance of Simulated Moving Bed Chromatography Exploiting Enrichment and Feed-Back Steps. Talk at 20th PREP Symposium 2007, Baltimore, USA, June 3-6, 2007

Keßler, L.C., Seidel-Morgenstern, A. (2007). Kontinuierliche Gruppentrennung für die large-scale Aufarbeitung biotechnologischer Produkte mittels Simulated Moving Bed-Chromatographie. Talk at Dechema/GVC Tagung Aufarbeitung biotechnologischer Produkte, Osnabrück, Germany, May 13 – 16, 2007

Keßler, L.C., Gueorguieva, L., Seidel-Morgenstern, A. (2007). Stufengradienten für die kontinuierliche Aufreinigung therapeutischer Proteine mittels Simulated Moving Bed-Chromatographie. Talk at Fachtagung Adsorption, Extraktion und Molecular Modelling 2007, Asselheim, Germany, March 21-23, 2007

Seidel-Morgenstern, A. (2007). Preparative Gradient Chromatography. Talk at Enantiosep '07 - Workshop-Symposium on Analytical and Preparative Enantioseparation, Ferrara, Italy, April 2, 2007

2006

A. Seidel-Morgenstern. Discontinuous and Continuous Operating Modes in Preparative Chromatography. AIChE Annual Meeting, San Francisco, USA, 12.-17.11.2006

L. C. Kessler, A. Seidel-Morgenstern. Purification of Immunoglobulin G using different matrices in simulated moving bed chromatography. Poster, ISPPP 2006 : 26th International Symposium on the Separation of Proteins, Peptides and Polynucleotides, Innsbruck, Austria, 18.-20.10.2006

L. Gueorguieva, L. C. Kessler, A. Seidel-Morgenstern. Applying Gradient SMB Processes for the Isolation of Proteins and Antibodies. PREP 2006 : 19th International Symposium, Exhibit and Workshops on Preparative / Process Chromatography, Ion Exchange, Adsorption/Desorption, Processes & Related Separation Techniques, Baltimore, USA, 14.-17.05.2006

A. Seidel-Morgenstern. Neue Entwicklungen auf dem Gebiet der kontinuierlichen Gegenstromchromatographie. Chromatographie-Symposium, Berlin, 12.09.2006

A. Seidel-Morgenstern. Kopplung von Chromatographie und Kristallisation zur Trennung von Enantiomeren. GDCh Köln, Institutskolloquium, Köln, 13.01.2006

2005

Seidel-Morgenstern, A. (2005). Gradient operation in preparative chromatography. 6th Dechema-Course "Design and Operation of Preparative and Production Scale Chromatographic Processes", 07.-09.03.2005, Universität Dortmund, Vortrag

Ziomek, G., Shan, Y., Antos, D., Seidel-Morgenstern, A. (2005). Comparing Different Options How to Apply Five Identical Columns in Preparative. Chromatography. PREP 2005, 18th International Symposium on Preparative and. Industrial Chromatography, 08.-11-05.2005, Philadelphia, USA, Vortrag

Balleda, A., Pushpavanam, S., Nayak, D., Gueorguieva, L., Seidel-Morgenstern, A. (2005). Analysis of Breakthrough Behavior in Fixed Bed and Expanded Bed. Adsorption. PREP 2005, 18th International Symposium on Preparative and. Industrial Chromatography, 08.-11-05.2005, Philadelphia, USA, Poster

Vu Dinh, T., Grüner, S. , Kienle, A., Seidel-Morgenstern. A. (2005). Analysis of Ester Hydrolysis Reactions in a Chromatographic Reactor Using Equilibrium. Theory and a Rate Model, CAMURe-5 & ISMR-4, 5th International Symposium on Catalysis on Multiphase Reactors & 4th International Symposium on. Multifunctional Reactors, 15.-18.0.62005, Portoroz, Slowenien, Vortrag

2004

Gueorguieva L., Vellejo L.F., Rinas U., Seidel-Morgenstern A. (2004). Einfluss des Salzgehaltes auf die Adsorptionsgleichgewichte und das Elutionsverhalten der Monomeren und Dimere des humanen Knochenwachstumsfaktors BMP-2. Bioperspectives, GVC/Dechema, Wiesbaden

2002

Gueorguieva, L., Beltcheva, D., Antos, D., Seidel-Morgenstern, A. (2002). Adsorption from solvent mixtures with varying composition, in: Fundamentals of Adsorption, Ed. K. Kaneko, H. Kanoh, Y. Hanzawa, IK International, Chiba–City, Japan , 1070-1077

Gueorguieva, L., Seidel-Morgenstern, A. (2002). Non-equilibrium effects in gradient elution chromatography. SPICA 2002, Internat. Symp. on Preparative and Industrial Chromatography and Allied Techniques, Book of Abstracts, Heidelberg

 

Patente/ Patents

Keßler L. C., Seidel-Morgenstern A. (2009). Verfahren und Vorrichtung zur chromatographischen Trennung von. Komponenten mit teilweiser Rückführung von Gemischfraktionen. EU 07007765 (angemeldet: 17.04.2007, geprüft: 7.12.2009)

Schramm, H., Kaspereit, M., Kienle, A., Seidel-Morgenstern A. (2002) Verfahren zur chromatographischen Trennung von Komponenten. Patent DE 102 35 385.9

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