http://www.tu-braunschweig.de http://sfb578.tu-braunschweig.de
Geschäftsführung
Mitglieder
Ziele
Projektbereiche
Publikationen
Presse
Preise
Termine
Kontakt
Impressum

B5 Systembiotechnologie der Produktbildung bei Bakterien

(Deckwer; Komm. Leitung: Hempel, Jahn, Franco-Lara)

B5 (ab 2. Förderphase), siehe auch A5

Publikationen/ Publications

2007

Biedendieck, R., Yang, Y., Deckwer, W.D., Malten, M., Jahn, D. (2007). Plasmid system for the intracellular production and purification of affinity-tagged proteins in Bacillus megaterium. Biotechnol Bioeng. 96(3):525-37

Fürch, T., Wittmann, C., Wang, W., Franco-Lara, E-, Jahn, D., Deckwer, W.-D. (2007). Effect of different carbon sources on central metabolic fluxes and recombinant protein production in Bacillus megaterium. Journal of Biotechnology 132 (4), 385-394

Fürch, T., Hollmann, R., Wittmann, C., Wang, W., Deckwer, W.D. (2007). Comparative study on central metabolic fluxes of Bacillus megaterium strains in continuous culture using (13)C labelled substrates. Bioprocess Biosyst Eng. 30(1):47-59

Yang, Y., Malten, M., Grote, A., Jahn, D., Deckwer, W.D. (2007). Codon optimized Thermobifida fusca hydrolase secreted by Bacillus megaterium. Biotechnol Bioeng. 2006 Aug 31; [Epub ahead of print]

2006

Deckwer, W.D., Jahn, D., Zeng, A.P., Hempel, D.C. (2006). Systembiotechnologische Ansätze zur Prozessentwicklung. Chemie-Ingenieur-Technik, 78:193-208

Fürch, T., Hollmann, R., Wang, W., Wittmann, C., Deckwer, W.D. (2006). Dynamische Untersuchungen zum Aminosäure-Stoffwechsel von Bacillus megaterium mittels stabiler Isotope. Chemie-Ingenieur-Technik, 78:295-300

Hollmann, R., Malten, M., Biedendieck R, Yang, Y., Wang, W., Jahn, D., Deckwer W.D. (2006). Bacillus megaterium als Produktionssystem für rekombinante Proteine. Chemie-Ingenieur-Technik, 78:289-294

Sun, J., Wang, W., Hundertmark, C., Zeng, A.P., Jahn, D., Deckwer, W.D. (2006) A protein database constructed from low-coverage genomic sequence of Bacillus megaterium and its use for accelerated proteomic analysis. J Biotechnol. 124(3):486-95

Wang, W., Hollmann, R., Deckwer, W.D. (2006). Comparative proteomic analysis of high cell density cultivations with two recombinant Bacillus megaterium strains for the production of a heterologous dextransucrase. Proteome Sci. 4:19

Wang, W., Sun, J., Hollmann, R., Zeng, A.P., Deckwer, W.D. (2006). Proteomic characterization of transient expression and secretion of a stress-related metalloprotease in high cell density culture of Bacillus megaterium. J Biotechnol. 126(3):313-24

Yang, Y., Biedendieck R, Wang, W., Gamer, M., Malten, M., Jahn, D., Deckwer, W.D. (2006). High yield recombinant penicillin G amidase production and export into the growth medium using Bacillus megaterium. Microb Cell Fact. 5(1):36

2005

Kim, E.J., Wang, W., Deckwer, W.D., Zeng, A.P. (2005). Expression of the quorum-sensing regulatory protein LasR is strongly affected by iron and oxygen concentrations in cultures of Pseudomonas aeruginosa irrespective of cell density. Microbiology. 2005 Apr;151(Pt 4):1127-38.

Malten, M., Hollmann, R., Deckwer, W.D., Jahn, D. (2005). Production and secretion of recombinant Leuconostoc mesenteroides dextransucrase DsrS in Bacillus megaterium. Biotechnol Bioeng. 2005 Jan 20;89(2):206-18

Medronho, R.A., Schütze, J., Deckwer, W.D. (2005). Numerical simulation of hydrocyclones for cell separation. Latin Am Appl Res, 35, 1-8

Wang, W., Hollmann, R., Fürch, T., Nimtz, M., Malten, M., Jahn, D., Deckwer W.D. (2005). Proteome analysis of a recombinant Bacillus megaterium strain during heterologous production of a glucosyltransferase. Proteome Sci. 2005 May 31;3:4

 

Buchveröffentlichungen/ Realeased Books

Zeng, A.P., Sun, J., Wang, W., Ma, H.W., Deckwer, W.D. (2006). Chapter 2. Application of Genomic and Proteomic Data for Bioprocess Analysis and Optimization. Yang, S. T. (ed.) Bioprocessing for value-added products from renewable resources. Elservier Inc, USA (2006)

 

Vorträge und Poster

2007

Fürch, T., Yang, Y., Wang, W., Franco-Lara, E., Jahn, D., Hempel, D.-H. (2007). Multi-substrate cultivation strategy for enhanced recombinant protein production in Bacillus megaterium. Proceedings from the “European BioPerspectives.” From 31st  May – 1st  June 2007 in Cologne, Germany.

2006

Deckwer, W.D. (2006). Mikrobieller und enzymatischer Abbau von Polyestern. 04.05.2006, Technische Universität Hamburg-Harburg

Fürch, T., Hollmann, R., Wang, W., Wittmann, C., Deckwer, W.D. (2006) . Metabolic fluxes in continuous cultures of recombinant Bacillus megaterium. VAAM, 19.03.-22.03.2006, Jena, Germany (Vortrag)

Fürch, T., Hollmann, R., Wang, W., Wittmann, C., Deckwer, W.D. (2006). Vergleichende Fluxomanalyse kontinuierlicher rekombinanter Bacillus megaterium-Kulturen. VDI/Dechema FA-Tagung „Industrielle Biotechnologie und Gewinnung von Produkten“, 22.05.-24.05.2006, Würzburg, Germany (Vortrag)

Fürch, T., Hollmann, R., Wang, W., Wittmann, C., Deckwer, W.D. (2006). Metabolic flux analysis of Bacillus megaterium strains by 13C substrates. Society for Industrial Microbiology, 30.07.-03.08.2006, Baltimore, Maryland, USA (Vortrag)

Yang, Y., Malten, M., Wang, W., Jahn, D., Deckwer, W.D. (2006). Expression and Secretion of Recombinant proteins in B. megaterium. VAAM, 19.03.-22.03.2006, Jena, Germany (Vortrag)

Fürch, T., Hollmann, R., Wang, W., Wittmann, C., Deckwer, W.D. (2006). Comparative fluxome analysis of continuous cultures of recombinant Bacillus megaterium strains. Metabolic Engineering VI: From recDNA towards Engineering Biological Systems, 01.10.-05.10.2006, Noordwijkerhout, The Netherlands (Poster)

Yang, Y., Malten, M., Biedendieck, R., Jahn, D., Deckwer, W.D. (2006). Optimization of protein production and secretion in Bacillus megaterium. 4th Recombinant Protein Production meeting, 20.09.06-23.09.06, Barcelona, Spain (Poster)

2005

Deckwer, W.D., Sun, J., Zeng, A.P., Fürch, T., Jahn, D., Hempel, D.C. (2005). Systembiotechnologische Ansätze zur Prozessentwicklung. Proc. GVC/DECHEMA-Vortrags- und Diskussionstagung „Systembiotechnologie für industrielle Prozesse“, Mai 2005, Braunschweig, Germany (Vortrag).

Deckwer, W.D. (2005). Rekombinante Proteine aus Bacillus megaterium. 15.06.2005, Universität Stuttgart (Vortrag).

Hollmann, R., Wang, W., Malten, M., Yang, Y., Biedendieck, R., Ma, C., Jahn, D., Deckwer, W.D. (2005). Bacillus megaterium als Produktionssystem für rekombinante Proteine. Proc. GVC/DECHEMA-Vortrags- und Diskussionstagung „Systembiotechnologie für industrielle Prozesse“, Braunschweig, Germany (Vortrag) (2005)

 

<< zurück zum Überblick / back