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B4 Systembiotechnologie der Produktbildung durch Aspergillus niger

(Jahn/Nörtemann/Jänsch)

Publikationen/ Publications

2009

Melzer G., Eslahpazir M., Franco-Lara E., Wittmann C. (2009) Flux Design: In silico design of cell factories based on correlation of pathway fluxes to desired properties. BMC Syst. Biol. 3:120.

2007

Melzer, G., Dalpiaz, A., Kucklick, M., Göcke, A., Grote, A., Jonas, R., Dersch, P., Franco-Lara, E., Nörtemann, B., Hempel, D.C. (2007). Metabolic flux analysis using stoichiometric models for Aspergillus niger: Comparison under glucoamylase-producing and non-producing conditions. J. Biotechnol. eingereicht

Melzer, G., Dalpiaz, A., Göcke, A., Grote, A., Kucklick, M., Franco-Lara, E., Dersch, P., Nörtemann, B., Hempel, D.C. (2007). Metabolic flux analysis applications to Aspergillus niger. AB1.13, 10th International Conference on Computer Applications in Biotechnology, Cancún, México. To be published by IFAC/Elsevier (Michel Perrier)

Pel,H.J., de Winde,J.H., Archer,D.B., Dyer,P.S., Hofmann,G., Schaap,P.J., Turner,G., de Vries,R.P., Albang,R., Albermann,K., Andersen,M.R., Bendtsen,J.D., Benen,J.A., van den,B.M., Breestraat,S., Caddick,M.X., Contreras,R., Cornell,M., Coutinho,P.M., Danchin,E.G., Debets,A.J., Dekker,P., van Dijck,P.W., van Dijk,A., Dijkhuizen,L., Driessen,A.J., d'Enfert,C., Geysens,S., Goosen,C., Groot,G.S., de Groot,P.W., Guillemette,T., Henrissat,B., Herweijer,M., van den Hombergh,J.P., van den Hondel,C.A., van der Heijden,R.T., van der Kaaij,R.M., Klis,F.M., Kools,H.J., Kubicek,C.P., van Kuyk,P.A., Lauber,J., Lu,X., van der Maarel,M.J., Meulenberg,R., Menke,H., Mortimer,M.A., Nielsen,J., Oliver,S.G., Olsthoorn,M., Pal,K., van Peij,N.N., Ram,A.F., Rinas,U., Roubos,J.A., Sagt,C.M., Schmoll,M., Sun,J., Ussery,D., Varga,J., Vervecken,W., van de Vondervoort,P.J., Wedler,H., Wosten,H.A., Zeng,A.P., van Ooyen,A.J., Visser,J., Stam,H. (2007). Genome sequencing and analysis of the versatile cell factory Aspergillus niger. CBS 513.88. Nat.Biotechnol. 25,221-231 (in Kooperation mit B6)

2006

El-Enshasy, H., Kleine, J. and Rinas, U. (2006). Agitation effects on morphology and protein productive fractions of filamentous and pelleted growth forms of recombinant Aspergillus niger. Process Biochem., 41, 2103-2112

2005

Wendler, J., Vallejo, L. F., Rinas, U., Bilitewski, U. (2005). Application of an SPRbased receptor assay for the determination of biological active recombinant bone morphogenetic protein-2. Anal. Bioanl. Chem. , 381, 1056-1064

Kadow, S., Betiku, E., Rinas, U. and Bilitewski, U. (2005). Development of a rapid, quantitative glucosyltransferase assay based on a screen-printed fructose enzyme electrode and application to optimization studies on gtfD expression in recombinant Escherichia coli. Biotechnol. Bioeng., accepted

Grote, A., Hiller, K., Scheer, M., Münch, R., Noertemann, B., Hempel D. C. and. Jahn, D. (2005). Jcat: a novel tool to adapt codon usage of a traget gene ot ists. potential expression host. W526-W531 Nucleic Acids Research, 2005, Vol. 33. Web Server issue doi:10.1093/nar/gki376

 

Vorträge und Poster/ Conference Presentations

2009

Melzer G, Eslahpazir M, Franco-Lara E, Nörtemann B, Hempel DC, Wittmann C (2009) Elementary mode analysis of Aspergillus niger metabolic network for optimization of recombinant sucrase production. 27th DECHEMA Jahrestagung der Biotechnologen, 08. – 10. September, Mannheim, Deutschland

2008

Melzer G, Eslahpazir Esfandabadi M, Dalpiaz A, Kucklick M, Nörtemann B, Jahn D, Hempel DC, Franco-Lara E (2008) Elementarmodi bei Aspergillus niger: Wege zur Proteinproduktion. GVC/Dechema Vortrags- und Diskussionstagung: Modellierung: Von der Zelle zum Prozess, 28. – 30. April, Bremen, Deutschland

2007

Melzer, G., A. Dalpiaz, Y. Göcke, A. Grote, M. Kucklick, E. Franco-Lara, P. Dersch, B. Nörtemann und D. C. Hempel (2007). Metabolic flux analysis of glucoamylase-producing fungus Aspergillus niger. AB1.13 cultivations European Bioperspectives, Koeln, Germany

Dalpiaz, A., K. Bohle, Y. Göcke, A. Grote, R. Jonas, M. Kucklick, G. Melzer, B. Nörtemann, E. Franco-Lara, P. Dersch, D.C. Hempel (2007). Influence of process conditions on glucoamylase production in continuous cultures of Aspergillus niger. AB1.13 7th Carbohydrate Bioengineering Meeting, April 22 – 25, Braunschweig, Germany

Dalpiaz, A., K. Bohle, Y. Göcke, A. Grote, R. Jonas, M. Kucklick, G. Melzer, B. Nörtemann, E. Franco-Lara, P. Dersch, D.C. Hempel (2007). Influence of process conditions on glucoamylase production in continuous cultures of Aspergillus niger . AB1.13. VAAM 2007, April 01-04, Osnabrück, Germany

2006

Dalpiaz, A., A. Grote, M. Kucklick, X. Lu, G. Melzer, M. Wurm, U. Rinas, B. Nörtemann, P. Dersch, D. Jahn, D.C. Hempel (2006). Systems biology of product and pellet formation in Aspergillus niger. VAAM 2006, März 19-22, Jena, Germany

2005

Lu. X. and Rinas. U. (2005). A proteomic approach to study cell physiology during glaA promoter controlled gene expression in Aspergillus niger. GVC/DECHEMAVortrags- und Diskussionstagung “Systembiotechnologie für industrielle Prozesse”, 01.-04.05.2005, Braunschweig, Poster

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