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A6 Produktion rekombinanter Antikörper in Bacillus megaterium und Aspergillus niger

(Dübel/Hust)

(ab 2. Förderphase)

Publikationen/ Publications

2009

Hust, M., Steinwand, M., Al-Halabi, L., Helmsing, S., Schirrmann, T. and Dübel, S. (2009). Improved microtitre plate production of single chain Fv fragments in Escherichia coli. New Biotechnology 25, 424-428

Jordan, E., Al-Halabi, L., Schirrmann, T. and Hust, M. (2009). Antibody production by the Gram-positive bacterium Bacillus megaterium. Therapeutic Antibodies, Ed: Dimitrov, A.S.,  Meth. Mol. Biol. 525 (2009)

2008

Schirrmann, T., Al-Halabi, L., Dübel, S. and Hust, M. (2008). Production systems for recombinant antibodies. Frontiers in Bioscience 13, 4576-4594

2007

Dübel, S. (2007). Recombinant therapeutic antibodies. App. Microbiol. Biotechnol.74, 723-729

Meyer V., Arentshorst M., El-Ghezal A., Drews C.D., Kooistra R., van den Hondel C., Ram A.F.J (2007). High efficient gene targeting in the Aspergillus niger kusA mutant. J Biotechnol 128,770-7

Jordan, E., Hust, M., Roth, A., Biedendieck, R., Schirrmann, T., Jahn, D., Dübel, S. (2007). Production of recombinant antibody fragments in Bacillus megaterium. Microbial Cell Factories 6:2

Biedendieck, R., Beine, R., Gamer, M., Jordan, E., Buchholz, K., Seibel, J., Dijkhuizen, L., Malten, M., Jahn, D. (2007). Export, purification and activities of affinity tagged Lactobacillus reuteri levansucrase produced by Bacillus megaterium. Appl Microbiol Biotechnol 74, 1062-1073

Jordan, E., Al-Halabi, L., Schirrmann, T., Hust, M. and Dübel, S. (2007). Production of single chain Fab (scFab) in Bacillus megaterium. Microbial Cell Factories 6:38

2005

B. Voedisch , C. Menzel, E. Jordan, A. El-Ghezal, T. Schirrmann, M. Hust, T. Jostock (2005). Heterologe Expression von rekombinanten Proteinpharmazeutika. Laborwelt (2005), 3, 31-35

B. Voedisch, C. Menzel, E. Jordan, A. El-Ghezal, T. Schirrmann, M. Hust,
T. Jostock (2005). Expression rekombinanter Proteinpharmazeutika. Transkript, 7, 47-51

Seibel, J.; Hillringhaus, L.; Moraru, R. (2005). Microwave-assisted glycosylation for the synthesis of glycopeptides. Carbohydrate Research, in press

 

Vorträge und Poster/ Conference Presentations

2006

M. Hust (2006). Single chain Fab fragments (scFab) – a new antibody design. Braunschweig Antibody Workshop 2006

M. Hust, M. Kirsch, A. El-Ghezal, L. Al-Halabi, T. Brunn, T. Rülker, T. Meyer, S. Dübel, T. Schirrmann (2006). A cassette vector system for scFv phage display, production in E. Coli and Produktion of scFv-Fc fusion proteins in mammalian cells. Antibody Engineering and Immunotherapeutics for the 21st Century, 2006, San Diego, CA. USA

Hust M, Jostock T, Menzel C, Voedisch B, Mohr A, Brenneis M, Kirsch MI, Meier D, Dübel S. (2006). Single chain Fab (scFab). Antibody Engineering and Immunotherapeutics for the 21st Century, 2006. San Diego, CA

Jordan E, El-Ghezal A, Hust M, Dübel S. (2006). Recombinant antibodies: Expression in Bacillus megaterium and Aspergillus niger. Braunschweig Antibody Workshop 2006.

2005

Al-Halabi L, El-Ghezal A, Jordan E, Hust M, Jostock T, Dübel S. (2005). Recombinant antibodies: targets and tools of systems Biology. GVC- Vortrags- und Diskussionstagung “ Systembiotechnologie” 2005

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